The main reason for discontinuance of implanted etonogestrel (Nexplanon) is:

Discontinuation of implanted etonogestrel, known as Nexplanon, is predominantly linked to the experience of irregular bleeding. This symptom can be particularly significant because it affects many users' quality of life and overall satisfaction with the contraceptive method. Irregular bleeding may manifest as unpredictable spotting or changes in menstrual patterns, which can lead to frustration and concern about the reliability of contraception. The experience of these changes is often a primary reason for discontinuation, as many individuals prioritize stable menstrual cycles when choosing contraceptive options.

Other mentioned factors like weight gain, pregnancy, and breast tenderness can also influence users’ decisions to stop using Nexplanon; however, they tend to be less frequently cited reasons compared to irregular bleeding. Therefore, while each of those factors can play a role in a user's experience, irregular bleeding remains the most common and compelling reason for discontinuation of this contraceptive implant.