What is a significant risk associated with testosterone replacement therapy in older males?

Testosterone replacement therapy (TRT) in older males presents several potential risks, one of the most significant being cardiovascular risks, including an increased likelihood of myocardial infarction. This concern arises from the complex relationship between testosterone levels and cardiovascular health. Although testosterone can have beneficial effects such as improving muscle mass and bone density, in older populations, particularly those with pre-existing conditions or risk factors, increased testosterone levels can lead to adverse cardiovascular events.

Clinical studies have shown that TRT can result in an elevation of hematocrit levels, which may contribute to increased blood viscosity and put additional strain on the cardiovascular system. Furthermore, testosterone may influence lipid profiles and promote atherogenesis, potentially leading to plaque formation in blood vessels.

Understanding the balance between the potential health benefits of testosterone and the cardiovascular risks is crucial in managing older males who might require hormone therapy. Thus, it is crucial for healthcare providers to conduct thorough assessments and monitor any patients undergoing TRT for signs of cardiovascular complications.