What is a true statement regarding migraines?

Migraines are indeed most prevalent in premenopausal females, making this statement accurate. Studies have shown that hormonal fluctuations, particularly related to estrogen levels, can significantly influence the occurrence of migraines, which is why they are more common in women before menopause.

The link between estrogen and migraines is well-documented, with many women reporting migraine onset or exacerbation during specific phases of their menstrual cycle. This hormonal connection highlights the relevance of gender and hormonal factors in understanding migraine prevalence and triggers.

The other statements do not accurately reflect the established knowledge about migraines. Many migraine sufferers do experience an aura, but this characteristic is present in only a subset of patients, not the majority. Migraines are often unilateral and can be aggravated by various factors, not simply alleviated by mild analgesics or ice. The notion that migraines result from macrophage activity against myelin sheaths in the central nervous system is a misunderstanding of the pathophysiology behind migraines, which primarily involves neural and vascular mechanisms rather than direct immune cell attack on the nervous tissue.