Which statement is true regarding atopic dermatitis?

Atopic dermatitis, also known as eczema, is a chronic inflammatory skin condition characterized by itchy, red, and dry patches on the skin. The diagnosis of atopic dermatitis is primarily based on clinical history and symptoms, which typically includes a detailed patient history, physical examination of the skin, and an assessment of the presence of characteristic symptoms such as itching and skin lesions.

This approach allows healthcare providers to identify the condition accurately and differentiate it from other dermatological issues, as the clinical presentation can overlap with various other skin disorders. Additionally, patients may have a personal or family history of atopic diseases like asthma or allergic rhinitis, further supporting the diagnosis.

In contrast, while histamine can contribute to itching in some contexts, it is not the only pruritogen involved, and the diagnosis does not rely on immunoglobulin M levels, which are more relevant to allergic reactions. Furthermore, atopic dermatitis has been associated with the development of other allergic conditions, such as asthma and allergic rhinitis, highlighting its role in the atopic march.