Which vitamin deficiency is most commonly associated with peripheral neuropathy?

Peripheral neuropathy is often linked to vitamin deficiencies, particularly those in the B vitamin complex. Among these, vitamin B12 deficiency is the most commonly associated with this condition. Vitamin B12, also known as cobalamin, plays a crucial role in maintaining the health of nerve cells and the production of myelin, which is the protective sheath surrounding peripheral nerves. When there is a deficiency in vitamin B12, it can lead to demyelination and subsequent impairment in nerve conduction, resulting in symptoms of peripheral neuropathy, such as tingling, numbness, and weakness in the extremities.

While vitamin B6 and vitamin D deficiencies can also contribute to neurological issues, vitamin B12 is particularly significant for peripheral nerve health. Vitamin D primarily supports bone health and immune function, and while it has some roles in neuronal function, it is not typically singled out as a main contributor to peripheral neuropathy. Vitamin C deficiency, while it can have various health implications, is not directly linked to peripheral neuropathy in the same way as vitamin B12.

Therefore, the association between vitamin B12 deficiency and peripheral neuropathy is well-established in clinical practice and literature, making it the most recognized deficiency in this context.